Rhodionin

Overview

Rhodionin is an orally active, multifunctional antivirulence and cytoprotective agent that targets and inhibits Lipase , sortase A ( SrtA ), CYP2D6 ( IC 50 =0.761 μM), AChE ( IC 50 =2.43-57.5 μM), and DPPH free radicals ( IC 50 =19.49 μM). Rhodionin is isolable from the roots of Rhodiola crenulata . Rhodionin reduces postprandial serum triglyceride levels in mice by inhibiting lipase activity. Rhodionin also binds directly to SrtA to inhibit its transpeptidase activity, thereby reducing the fibrinogen adhesion and surface protein A levels of MRSA , effectively inhibiting biofilm formation and protecting against MRSA-induced cell damage. Rhodionin improves the survival rate of infected mice without affecting MRSA growth, and finds wide application in studies related to hyperlipidemia, exogenous obesity, and pneumonia induced by methicillin-resistant Staphylococcus aureus ( MRSA ).

Application

Products | Products > Disease Areas > Infection | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Bacterial Infection | Products > Disease Areas > Lipid Metabolism | Products > Disease Areas > Streptococcus Pneumoniae Infection | Products > Disease Areas > Obesity | Products > Disease Areas > Hyperlipidemia | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Metabolic Disease | Products > Research Areas > Infection | Products > Signaling Pathways > Cytochrome P450 | Products > Signaling Pathways > Free Radical Scavengers | Products > Signaling Pathways > Cholinesterase (ChE) | Products > Signaling Pathways > Lipase | Products > Signaling Pathways > Bacterial

Product Information

• Catalog No.: HY-N0241
• CAS No.: 85571-15-9
• Molecular Formula: C21H20O11
• Molecular Weight: 448.38
• Purity: 99.73%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 1.67 mg/mL (3.72 mM); Clear solution
• Availability: In-stock

Source

Original product source