Epmedin C (Epimedin-C; Baohuoside-VI) is an orally active anti-inflammatory agent and immunomodulator that binds to multiple key proteins including UCP1, Caspase-1 , CDK2 and Keap1 . Epmedin C inhibits epithelial cell proliferation by disrupting the complex function of CDK2 / Cyclin E . Epmedin C also upregulates Nrf2 expression, reduces ROS levels and inhibits pro-inflammatory cytokine secretion, thereby effectively restoring antibody production and alleviating tissue damage. Epmedin C has good safety with no hepatotoxicity or skin sensitization, and it has been used in studies on diseases such as obesity, Deoxynivalenol ( HY-N6684 )-induced immunotoxicity and mammary hyperplasia.
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