Daphnetin

Overview

Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne , is a potent, oral active protein kinase inhibitor, with IC 50 s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR , PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1β, ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research.

Application

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Product Information

• Catalog No.: HY-N0281
• CAS No.: 486-35-1
• Molecular Formula: C9H6O4
• Molecular Weight: 178.14
• Purity: 99.77%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (14.03 mM); Clear solution
• Availability: In-stock

Source

Original product source