Curdione (Standard)

Overview

Curdione (Standard) is the analytical standard of Curdione. This product is intended for research and analytical applications. Curdione ((+)-Curdione) is an orally active sesquiterpenoid. Curdione inhibits platelet aggregation. Curdione induces ferroptosis in colorectal cancer via m6A methylation mediated by METTL14 and YTHDF2 . Curdione inhibits ferroptosis in Isoproterenol ( HY-B0468 )-induced myocardial infarction by regulating the Keap1/Trx1/ GPX4 signaling pathway, suppressing oxidative stress ( ROS ) and apoptosis . Curdione ameliorates Doxorubicin ( HY-15142 )-induced cardiotoxicity by inhibiting oxidative stress ( ROS ) and activating the Nrf2 / HO-1 pathway. Curdione ameliorates sepsis-induced lung injury by inhibiting platelet-mediated neutrophil extracellular trap formation. Curdione ameliorates Bleomycin ( HY-17565A )-induced pulmonary fibrosis by inhibiting TGF-β -induced fibroblast-to-myofibroblast differentiation. Curdione exhibits neuroprotective effects against focal cerebral ischemia-reperfusion injury in rats. Curdione exerts antiproliferative effects against human uterine leiomyosarcoma by targeting IDO1 . Curdione protects vascular endothelial cells and atherosclerosis by regulating DNMT1-mediated ERBB4 promoter methylation. Curdione inhibits inducible prostaglandin E2 production ( IC 50 = 1.1 μM) and cyclooxygenase 2 expression.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Others | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > TGF-beta/Smad | Products > Research Areas > Others | Products > Signaling Pathways > Ferroptosis | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Reactive Oxygen Species (ROS) | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Glutathione Peroxidase | Products > Signaling Pathways > Keap1-Nrf2 | Products > Signaling Pathways > Heme Oxygenase (HO) | Products > Signaling Pathways > TGF-β Receptor | Products > Signaling Pathways > Indoleamine 2,3-Dioxygenase (IDO) | Products > Signaling Pathways > Reference Standards

Product Information

• Catalog No.: HY-N0353R
• CAS No.: 13657-68-6
• Molecular Formula: C15H24O2
• Molecular Weight: 236.35
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source