(+)-Columbianetin

Overview

(+)-Columbianetin ((S)-Columbianetin) acts as an inhibitor of JNK / ERK . (+)-Columbianetin inhibits UVA-induced phosphorylation of JNK and ERK , reduces the production of MMP-1 , reverses UVA-induced Collagen ( HY-NP003 ) degradation, and alleviates UVA-mediated inhibition of Smad2/3 phosphorylation and translocation. (+)-Columbianetin regulates the AP-1 and ASK1-MAPK signaling pathways, inhibits the production of ROS and blocks sub-G 1 cell cycle arrest. (+)-Columbianetin is applicable to research related to skin aging.

Application

Products | Products > Disease Areas > Others | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Cytoskeleton | Products > Signaling Pathways > TGF-beta/Smad | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Others | Products > Signaling Pathways > JNK | Products > Signaling Pathways > Collagen | Products > Signaling Pathways > TGF-beta/Smad | Products > Signaling Pathways > p38 MAPK | Products > Signaling Pathways > Reactive Oxygen Species (ROS) | Products > Signaling Pathways > ERK

Product Information

• Catalog No.: HY-N0363
• CAS No.: 3804-70-4
• Molecular Formula: C14H14O4
• Molecular Weight: 246.26
• Purity: 99.04%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 2.5 mg/mL (10.15 mM); Clear solution
• Availability: In-stock

Source

Original product source