Maackiain

Overview

Maackiain (DL-Maackiain) is an orally active multi-target inhibitor with anti-tumor activity and neuroprotective effects. Maackiain activates the AMPK , NLRP3 and Nrf2/HO-1 pathways, and inhibits key targets such as NF-κB , mTOR , MAO-B , NFATc1 and PKCδ , thereby precisely regulating processes including apoptosis , autophagy and pyroptosis . Maackiain also effectively inhibits microglial activation, osteoclast formation, and proliferation and invasion of tumor cells, and protects dopaminergic neurons from damage. Maackiain is applicable to the research of various diseases such as Alzheimer's disease, osteoporosis, sepsis and dengue fever。

Application

Products | Products > Disease Areas > Infection | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Viral Infection | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Mineral Metabolism | Products > Disease Areas > Flavivirus Infection | Products > Disease Areas > Alzheimer's Disease | Products > Disease Areas > Osteoporosis | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > TGF-beta/Smad | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Neurological Disease | Products > Research Areas > Metabolic Disease | Products > Research Areas > Infection | Products > Signaling Pathways > Keap1-Nrf2 | Products > Signaling Pathways > p38 MAPK | Products > Signaling Pathways > NOD-like Receptor (NLR) | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > mTOR | Products > Signaling Pathways > Monoamine Oxidase | Products > Signaling Pathways > Nuclear Factor of activated T Cells (NFAT) | Products > Signaling Pathways > PKC | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Pyroptosis | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Dengue Virus

Product Information

• Catalog No.: HY-N0381
• CAS No.: 19908-48-6
• Molecular Formula: C16H12O5
• Molecular Weight: 284.27
• Purity: 99.83%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 2.08 mg/mL (7.32 mM); Clear solution
• Availability: In-stock

Source

Original product source