Polygalasaponin F (Standard)

Overview

Polygalasaponin F (Standard) is the analytical standard of Polygalasaponin F. This product is intended for research and analytical applications. Polygalasaponin F is an orally active triterpenoid saponin monomer. Polygalasaponin F downregulates the expression of Bax , p53 , caspase-3 , NF-κB p65 and MEK1 ; restores and upregulates the expression of Bcl-2 ; activates the PI3K/Akt signaling pathway; inhibits the phosphorylation of p38 MAPK , nuclear translocation of NF-κB , TLR4 -mediated signaling pathway, mitophagy ( Mitophagy ) and ROS production; enhances cell viability and suppresses apoptosis ( Apoptosis ). Polygalasaponin F maintains mitochondrial function, alleviates Ca 2+ overload, upregulates pCREB and BDNF , preserves cell viability and inhibits the release of inflammatory cytokines. Polygalasaponin F alleviates lung injury induced by influenza A H1N1 and cerebral ischemia-reperfusion injury. Polygalasaponin F is applicable to researches related to Parkinson's disease, cerebral ischemia, pneumonia induced by influenza A H1N1 , stroke and Alzheimer's disease.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Others | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > NF-κB | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Reference Standards | Products > Signaling Pathways > Toll-like Receptor (TLR) | Products > Signaling Pathways > PI3K | Products > Signaling Pathways > Akt

Product Information

• Catalog No.: HY-N0392R
• CAS No.: 882664-74-6
• Molecular Formula: C53H86O23
• Molecular Weight: 1091.24
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source