GSK1016790A

Overview

GSK1016790A is a novel and potent transient receptor potential vanilloid 4 (TRPV4) agonist. It has been used to demonstrate a role for TRPV4 in regulating urinary bladder activity and endothelial control of vascular tone. It elicited Ca2+ influx in mouse and human TRPV4 expressing HEK cells with EC50 values of 18 and 2.1 nM, respectively. It also evoked a dose-dependent activation of TRPV4 whole-cell currents at concentrations above 1 nM, which is 300 fold more potent than 4a-PDD. It was developed by GlaxoSmithKline.

Application

Products > Drug Discovery > Inhibitor | Products > Drug Discovery > Inhibitor | Cardiovascular and blood system | TRP Channel

Product Information

• Catalog No.: B0084-382782
• CAS No.: 942206-85-1
• Molecular Formula: C28H32Cl2N4O6S2
• Molecular Weight: 655.61
• Purity: >98 %
• Storage: -20°C Freezer
• Solubility: DMSO ≥ 33 mg/mL

Source

Original product source