8-Gingerol

Overview

8-Gingerol can be found in the rhizome of ginger ( Z. officinale ) and has oral bioactivity. It activates TRPV1 , with an EC 50 value of 5.0 µM. 8-Gingerol inhibits COX-2 and also suppresses the growth of H. pylori in vitro. Additionally, 8-Gingerol exhibits anticancer , antioxidant, and anti-inflammatory properties by inhibiting the epidermal growth factor receptor ( EGFR ) and modulating its downstream STAT3/ERK pathway to suppress the proliferation, migration, and invasion of colorectal cancer cells. 8-Gingerol also exerts immunosuppressive effects by inhibiting oxidative stress, inducing cell cycle arrest, promoting apoptosis , and regulating autophagy . Furthermore, 8-Gingerol has cardioprotective effects. 8-Gingerol is promising for research in the fields of cancer , infection , immunosuppression, and cardiovascular diseases.

Application

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Product Information

• Catalog No.: HY-N0447
• CAS No.: 23513-08-8
• Molecular Formula: C19H30O4
• Molecular Weight: 322.44
• Purity: 99.82%
• Storage: -20°C, sealed storage, away from moisture and light * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Solubility: ≥ 2.5 mg/mL (7.75 mM); Clear solution
• Availability: In-stock

Source

Original product source