Vincristine sulfate

Overview

Vincristine (Leurocristine; NSC-67574; 22-Oxovincaleukoblastine) sulfate is a microtubule inhibitor that disrupts microtubule polymerization by binding to β-tubulin (with a K i of 85 nM in bovine), arrests the cell cycle and induces apoptosis . Vincristine sulfate inhibits cell replication, tumor blood flow and the proliferation of various cancer cells, while triggering effects such as oxidative stress, inflammation, calcium overload, epithelial-mesenchymal transition and peripheral neuropathic pain. Vincristine sulfate upregulates the expression of various transporters and nuclear receptors, and enriches gastric cancer stem-like cells. Vincristine sulfate is used in research related to various tumors including acute lymphoblastic leukemia, lymphoma, melanoma, gastric cancer , solid tumors and sarcomas.

Application

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Product Information

• Catalog No.: HY-N0488
• CAS No.: 2068-78-2
• Molecular Formula: C46H58N4O14S
• Molecular Weight: 923.04
• Purity: 99.43%
• Storage: 4°C, sealed storage, away from moisture and light * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Solubility: ≥ 4.17 mg/mL (4.52 mM); Clear solution
• Availability: In-stock

Source

Original product source