Cornuside

Overview

Cornuside is an iridoid glycoside with anti-allergic, anti-inflammatory, and neuroprotective activities. Cornuside exerts anti-allergic activity by downregulating the p38 MAPK , JNK , and NF-κB signaling pathways, and inhibits IgE-mediated histamine release from mast cells. Cornuside improves cognitive impairment in mice by inhibiting BACE1 activity ( IC 50 = 55.84 μg/mL) and enhancing ChAT activity. Cornuside inhibits LPS ( HY-D1056 )-induced inflammatory mediators, including iNOS , COX-2 , PGE2 , TNF-α , IL-6 , and IL-1β , by suppressing NF-κB activation.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Allergy | Products > Disease Areas > Alzheimer's Disease | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Stem Cell/Wnt | Products > Research Areas > Neurological Disease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Free Radical Scavengers | Products > Signaling Pathways > p38 MAPK | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > JNK | Products > Signaling Pathways > Cholinesterase (ChE) | Products > Signaling Pathways > Acyltransferase | Products > Signaling Pathways > NO Synthase | Products > Signaling Pathways > Interleukin Related | Products > Signaling Pathways > TNF Receptor | Products > Signaling Pathways > Prostaglandin Receptor | Products > Signaling Pathways > ERK | Products > Signaling Pathways > COX

Product Information

• Catalog No.: HY-N0631
• CAS No.: 131189-57-6
• Molecular Formula: C24H30O14
• Molecular Weight: 542.49
• Purity: 99.99%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 2.5 mg/mL (4.61 mM); Clear solution
• Availability: In-stock

Source

Original product source