(+)-Usnic acid is isolated from isolated from lichens, binds at the ATP-binding pocket of mTOR , and inhibits mTORC1/2 activity. (+)-Usnic acid inhibits the phosphorylation of mTOR downstream effectors: Akt (Ser473), 4EBP1, S6K, induces autophay , with anti-cancer and anti-inflammatory activity. (+)-Usnic acid possesses antimicrobial activity against a number of planktonic gram-positive bacteria, including Staphylococcus aureus , Enterococcus faecalis , and Enterococcus faecium .
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