Daphnoretin (Dephnoretin; Thymelol) (Standard) is the analytical standard of Daphnoretin ( HY-N0699 ). This product is used for research and analytical applications. Daphnoretin is a protein kinase C ( PKC ) activator that can inhibit the expression of hepatitis B virus ( HBV ) surface antigen (HBsAg) and has antiviral activity. Daphnoretin exerts its anti-tumor effect by inhibiting the activation of the PI3K/AKT signaling pathway, triggering the mitochondrial apoptosis pathway. Daphnoretin alleviates chondrocyte apoptosis and inflammatory responses by inhibiting endoplasmic reticulum stress and the activation of the NLRP3 inflammasome. Daphnoretin can regulate the differentiation and maturation of dendritic cells, by down-regulating the phosphorylation level of JNK , inhibiting its immune stimulating function, thereby playing a protective role in skin transplant rejection reactions.
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