Jolkinolide B

Overview

Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud with oral activity. Jolkinolide B downregulates XIAP , cIAP1 , cIAP2 , and phosphorylated Akt , upregulates Smac , activates caspase-3 and caspase-9 , and inhibits NF-κB , TGFβ/smad3 and JAK/STAT3 pathways. Jolkinolide B exerts comprehensive biological effects including inducing cancer cell apoptosis , suppressing inflammatory responses, improving lung function, alleviating hepatic steatosis and eliminating intracellular Mycobacterium tuberculosis . Jolkinolide B can be used for the research of leukemia, histiocytic lymphoma, asthma, metabolic dysfunction-associated steatotic liver disease and tuberculosis.

Application

Products | Products > Disease Areas > Infection | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Cancer | Products > Disease Areas > Bacterial Infection | Products > Disease Areas > Lower Respiratory Inflammation | Products > Disease Areas > Respiratory Inflammation | Products > Disease Areas > Lipid Metabolism | Products > Disease Areas > Mycobacterium Tuberculosis Infection | Products > Disease Areas > Asthma | Products > Disease Areas > Fatty Liver Disease | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > TGF-beta/Smad | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Metabolic Disease | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Infection | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > IAP | Products > Signaling Pathways > Akt | Products > Signaling Pathways > Caspase | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > TGF-beta/Smad | Products > Signaling Pathways > JAK | Products > Signaling Pathways > Bacterial | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-N0732
• CAS No.: 37905-08-1
• Molecular Formula: C20H26O4
• Molecular Weight: 330.42
• Purity: 99.65%
• Storage: -20°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 0.83 mg/mL (2.51 mM); Clear solution
• Availability: In-stock

Source

Original product source