Senkyunolide I

Overview

Senkyunolide I is an orally active, blood-brain barrier-permeable metabolite of Z-ligustilide ( HY-N0401A ) . Senkyunolide I is isolated from Ligusticum chuanxiong . Senkyunolide I upregulates p-Erk1/2 and Nrf2/HO-1 , and inhibits Caspase 3 . Senkyunolide I alleviates Apoptosis . Senkyunolide I increases the pain threshold in mice and reduces acetic acid-induced writhing responses in mice. Senkyunolide I improves neurological deficits, reduces infarct volume and alleviates cerebral edema in rats with focal cerebral ischemia-reperfusion injury. Senkyunolide I protects renal function and structural integrity in a mouse model of renal ischemia-reperfusion injury. Senkyunolide I is applicable to research related to focal cerebral ischemia-reperfusion injury, migraine, and renal ischemia-reperfusion injury.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Pain | Products > Disease Areas > Oxidative Stress and Inflammation | Products > Disease Areas > Nervous System Injury | Products > Disease Areas > Migraine | Products > Disease Areas > Ischemia-Reperfusion Injury | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Neurological Disease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Heme Oxygenase (HO) | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Caspase | Products > Signaling Pathways > ERK | Products > Signaling Pathways > Keap1-Nrf2

Product Information

• Catalog No.: HY-N0745
• CAS No.: 94596-28-8
• Molecular Formula: C12H16O4
• Molecular Weight: 224.26
• Purity: 99.37%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 2.5 mg/mL (11.15 mM); Clear solution
• Availability: In-stock

Source

Original product source