Deoxyandrographolide

Overview

Deoxyandrographolide is an orally active lactone found in the Andrographis paniculata Nees. Deoxyandrographolide shows a K D of 38.4 μM of HDAC1 . Deoxyandrographolide enhances GLUT4 plasma membrane translocation, activates PI3K and AMPK -dependent signaling pathways, suppresses fasting blood glucose, serum insulin , triglycerides, and LDL-cholesterol levels. Deoxyandrographolide enhances HDAC1 expression via inhibited ubiquitination degradation, represses H3K4me3 , improves chromosome stability, and restrains aging biomarkers p16 , p21 , γH2A.X , p53 and ROS production. Deoxyandrographolide interacts with Foot-and-Mouth Disease Virus 3Cpro active site, inhibits protease and IFN -antagonist activity, derepresses ISG expression, and inhibits viral replication. Deoxyandrographolide can be used for the researches of type 2 diabetes mellitus , vascular senescence and virus infection .

Application

Products | Products > Disease Areas > Infection | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > NF-κB | Products > Research Areas > Metabolic Disease | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Infection | Products > Signaling Pathways > GLUT | Products > Signaling Pathways > HDAC | Products > Signaling Pathways > Virus Protease | Products > Signaling Pathways > PI3K | Products > Signaling Pathways > AMPK | Products > Signaling Pathways > Akt | Products > Signaling Pathways > Histone Demethylase | Products > Signaling Pathways > MDM-2/p53 | Products > Signaling Pathways > IFNAR | Products > Signaling Pathways > Reactive Oxygen Species (ROS)

Product Information

• Catalog No.: HY-N0857
• CAS No.: 79233-15-1
• Molecular Formula: C20H30O4
• Molecular Weight: 334.45
• Purity: 99.80%
• Storage: -20°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 2.5 mg/mL (7.47 mM); Clear solution
• Availability: In-stock

Source

Original product source