Telocinobufagin

Overview

Telocinobufagin (Telobufotoxin; Telocinobufogenin) is an orally active bufadienolide with potential anti-tumor effects. Telocinobufagin exerts its anti-cancer effects on non-small cell carcinoma, osteosarcoma, thyroid cancer , breast cancer and head and neck squamous cell carcinoma by inhibiting the STAT3 , JAK2/STAT3 , LARP1-mTOR , PI3K/Akt/Snail and PLK1 pathways, and can also induce tumor cell apoptosis . Telocinobufagin enhances the Th1 immune response and protects against Salmonella typhimurium infection . Telocinobufagin has a strong cardiac-stimulating effect by inhibiting the activity of Na + /K + -ATPase , and it can promote renal fibrosis. Telocinobufagin demonstrates non-opioid analgesic effects in various acute pain models.

Application

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Product Information

• Catalog No.: HY-N0885
• CAS No.: 472-26-4
• Molecular Formula: C24H34O5
• Molecular Weight: 402.52
• Purity: 99.50%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.5 mg/mL (6.21 mM); Clear solution
• Availability: In-stock

Source

Original product source