Aloin B

Overview

Aloin B (Isobarbaloin) is an orally active SARS-CoV-2 papain-like protease ( PLpro ) inhibitor with an IC 50 of 16.08 μM (hydrolytic activity) and 17.51 μM ( deubiquitinase activity). Aloin B is metabolized by rat intestinal flora into aloe-emodin-9-anthrone to exert laxative effects. Aloin B inhibits TPA ( HY-18739 )-induced ear edema, putrescine elevation, and tumor promotion in mouse skin. Aloin B can be used in research related to anti-inflammation, tumor promotion inhibition, coronavirus disease 2019 (COVID-19) and constipation.

Application

Products | Products > Disease Areas > Constipation | Products > Disease Areas > SARS-CoV-2 Infection | Products > Disease Areas > Cancer | Products > Disease Areas > Infection | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Coronavirus Infection | Products > Disease Areas > Melanoma | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Infection | Products > Research Areas > Endocrinology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Signaling Pathways > SARS-CoV | Products > Signaling Pathways > Virus Protease

Product Information

• Catalog No.: HY-N0886
• CAS No.: 28371-16-6
• Molecular Formula: C21H22O9
• Molecular Weight: 418.39
• Purity: 99.15%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (5.98 mM); Clear solution
• Availability: In-stock

Source

Original product source