Isoastragaloside I

Overview

Isoastragaloside I is a natural compound found in Astragalus membranaceus , with oral activity and multiple biological activities such as anti-inflammatory and antioxidant properties. Isoastragaloside I inhibits Akt , NF-κB , MAPKs and PI3K , enhances the activity of hepatic FXR , regulates the TGF-β/Smads signaling pathway, and upregulates antioxidant molecules downstream of Nrf2 . Isoastragaloside I inhibits the expression of NO , TNF-α , iNOS , COX-2 , IL-1β and VCAM-1 , and reduces intracellular ROS levels. Isoastragaloside I attenuates blood-brain barrier disruption, restores intestinal barrier function, increases β-cell mass, improves glucose homeostasis, and elevates circulating adiponectin levels. Isoastragaloside I can be used for the study of neuroinflammation-related neurodegenerative diseases, cholestatic liver disease, and diabetes.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Autoimmune Disease | Products > Disease Areas > Glucose Metabolism | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > CNS Infection | Products > Disease Areas > Liver Disease | Products > Disease Areas > Type 1 Diabetes | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Cytoskeleton | Products > Signaling Pathways > TGF-beta/Smad | Products > Research Areas > Neurological Disease | Products > Research Areas > Metabolic Disease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > p38 MAPK | Products > Signaling Pathways > PI3K | Products > Signaling Pathways > FXR | Products > Signaling Pathways > Keap1-Nrf2 | Products > Signaling Pathways > NO Synthase | Products > Signaling Pathways > COX | Products > Signaling Pathways > Interleukin Related | Products > Signaling Pathways > Integrin | Products > Signaling Pathways > TGF-β Receptor | Products > Signaling Pathways > Reactive Oxygen Species (ROS) | Products > Signaling Pathways > Akt

Product Information

• Catalog No.: HY-N0887
• CAS No.: 84676-88-0
• Molecular Formula: C45H72O16
• Molecular Weight: 869.04
• Purity: 99.49%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 2.5 mg/mL (2.88 mM); Clear solution
• Availability: In-stock

Source

Original product source