19-epi-Scholaricine

Overview

19-epi-Scholaricine is an orally active indole alkaloid. 19-epi-Scholaricine downregulates the expression of profibrotic/ apoptotic proteins ( HRAS, HSP90AA1, KDR ) and upregulates the expression of cell cycle-related protein ( CDK2 ). 19-epi-Scholaricine suppresses ROS production and reduces the release of inflammatory mediators, thereby attenuating podocyte apoptosis , renal inflammation and oxidative stress by inhibiting AKT/mTOR . 19-epi-Scholaricine can be used in the research of chronic glomerulonephritis and membranous nephropathy.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Renal Disease | Products > Disease Areas > Genitourinary Inflammation | Products > Disease Areas > Nephritis | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Akt | Products > Signaling Pathways > mTOR | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Reactive Oxygen Species (ROS) | Products > Signaling Pathways > CDK | Products > Signaling Pathways > Ras | Products > Signaling Pathways > HSP | Products > Signaling Pathways > VEGFR | Products > Signaling Pathways > TNF Receptor | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-N10379
• CAS No.: 132923-06-9
• Molecular Formula: C20H24N2O4
• Molecular Weight: 356.42
• Purity: 99.14%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Availability: In-stock

Source

Original product source