Brazilein

Overview

Brazilein is a compound with anti-inflammatory and neuroprotective activities, with an IC 50 of 500 μM against guinea pig Na + ,K + -ATPase . Brazilein reduces iNOS mRNA expression, thereby inhibiting nitric oxide production in immune cells. Brazilein suppresses inflammatory responses by reducing the mRNA expression of TNF-α and IL-6 , but has no effect on IL-1β expression. Brazilein reduces the cerebral infarction volume and improves the neurological function scores of rats with cerebral ischemia-reperfusion injury. Brazilein induces apoptosis of splenic lymphocytes in mice. Brazilein inhibits humoral immune responses in mice, and causes thymus and spleen atrophy as well as body weight loss in mice. Brazilein also possesses antimalarial and antibacterial activities. Brazilein is also a red dye. Brazilein can be used in studies related to the infection , nervous system, cardiovascular system and inflammatory diseases.

Application

Products | Products > Disease Areas > Infection | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Neurological Disease | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Infection | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Bacterial | Products > Signaling Pathways > Parasite | Products > Signaling Pathways > Na+/K+ ATPase | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Interleukin Related | Products > Signaling Pathways > NO Synthase

Product Information

• Catalog No.: HY-N10424
• CAS No.: 600-76-0
• Molecular Formula: C16H12O5
• Molecular Weight: 284.26
• Purity: 99.9%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source