Bleomycin A5

Overview

Bleomycin A5 (Pingyangmycin) is a glycopeptide antibiotic with multiple biological activities, which can be isolated from Streptomyces . Bleomycin A5 exerts cytotoxic effects by binding to Fe 2+ to form a complex, inducing single-strand and double-strand DNA breaks, and inhibiting DNA replication. Bleomycin A5 inhibits Drp1 -mediated mitochondrial fission and suppresses PINK1/Parkin pathway-mediated mitophagy , ultimately triggering mitochondria-mediated cellular apoptosis . Bleomycin A5 can be used in cancer research.

Application

Products | Products > Disease Areas > Infection | Products > Disease Areas > Cancer | Products > Disease Areas > Bacterial Infection | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Cytoskeleton | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Autophagy | Products > Research Areas > Infection | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Dynamin | Products > Signaling Pathways > PINK1/Parkin | Products > Signaling Pathways > Mitophagy | Products > Signaling Pathways > Antibiotic | Products > Signaling Pathways > DNA/RNA Synthesis

Product Information

• Catalog No.: HY-N10470
• CAS No.: 11116-32-8
• Molecular Formula: C57H89N19O21S2
• Molecular Weight: 1440.56
• Purity: 99.81%
• Storage: 4°C, sealed storage, away from moisture and light * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Availability: In-stock

Source

Original product source