Sacubitril

Overview

Sacubitril, also known as AHU377 or LCZ696, is an angiotensin receptor neprilysin inhibitor being studied for use in combination with valsartan for heart failure. Sacubitril is a prodrug that is activated to LBQ657 by de-ethylation via esterases. LBQ657 inhibits the enzyme neprilysin, which is responsible for the degradation of atrial and brain natriuretic peptide, two blood pressure lowering peptides that work mainly by reducing blood volume.

Application

Products > Drug Discovery > Inhibitor | Products > Drug Discovery > Inhibitor | Alzheimer's disease | Neprilysin

Product Information

• Catalog No.: B0084-458470
• CAS No.: 149709-62-6
• Molecular Formula: C24H29NO5
• Molecular Weight: 411.49
• Purity: >98%
• Storage: Store at -20 °C

Source

Original product source