4-O-Methylepisappanol (compound 9) is nature product that could be isolated from heartwood of Caesalpinia sappan . 4-O-Methylepisappanol is a potent neuraminidase inhibitor on the surface of influenza viruses with IC 50 values of 42.8, 63.2, and 63.2 µM for A/Chicken/Korea/MS96/96 [H9N2], A/PR/8/34 [H1N1], and A/Hong Kong/8/68 [H3N2], respectively.
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