Sudachitin

Overview

Sudachitin is an orally active compound that potently inhibits mouse PDE1C and human PDE4B , with IC 50 values of 5.0 μM and 15.0 μM, respectively. Sudachitin upregulates Sirt1 and PGC‑1α expression in skeletal muscle to regulate energy metabolism and promote mitochondrial biogenesis. Sudachitin improves lipid metabolism, glucose tolerance, insulin sensitivity, energy expenditure, and fatty acid β‑oxidation. Sudachitin activates p38MAPK signaling, induces HSP27 phosphorylation and caspase‑dependent apoptosis , and blocks EGF ‑driven keratinocyte migration and proliferation. Sudachitin suppresses LPS‑induced TNF‑α , NO , and iNOS expression in macrophages and shows potent anti‑inflammatory activity. Sudachitin can be used for the research of metabolic syndrome, type 2 diabetes, and psoriasis..

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Metabolic Disease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > PGC-1α | Products > Signaling Pathways > p38 MAPK | Products > Signaling Pathways > HSP | Products > Signaling Pathways > TNF Receptor | Products > Signaling Pathways > NO Synthase | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Phosphodiesterase (PDE) | Products > Signaling Pathways > Sirtuin

Product Information

• Catalog No.: HY-N11262
• CAS No.: 4281-28-1
• Molecular Formula: C18H16O8
• Molecular Weight: 360.31
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source