Theasaponin E1

Overview

Theasaponin E1 is an orally effective tea saponin. Theasaponin E1 inhibits the proliferation of cancer cells by activating apoptosis . Theasaponin E1 inhibits angiogenesis in ovarian cancer cells and HUVECs by reducing the expression of VEGF . Theasaponin E1 upregulates the phosphorylation level of ATM protein and the expression level of PTEN protein in cancer cells, decreases the phosphorylation levels of Akt , mTOR , p70S6K and 4E-BP1 proteins, downregulates the expression of HIF-1α and NF-κB , and reduces the protein expression of Notch ligands Dll4 and Jagged1 . Theasaponin E1 exerts neuroprotective effects by inhibiting the activity of acetylcholinesterase , activating α-secretase and neprilysin , reducing the concentration of Aβ , and inhibiting the activities of β-secretase and γ-secretase . Theasaponin E1 exhibits toxic effects on cancer cells and quinone reductase-inducing activity, and inhibits tumor growth in vivo. Theasaponin E1 induces ferroptosis in Pomacea canaliculata by synergistically disrupting cholesterol homeostasis and sphingolipid metabolism. Theasaponin E1 possesses anti-biofilm activity against Candida albicans . Theasaponin E1 can be used in the research of ovarian cancer , obesity, Alzheimer's disease and fungal infections.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Infection | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Lipid Metabolism | Products > Disease Areas > Ovarian Cancer | Products > Disease Areas > Urogenital Cancer | Products > Disease Areas > Fungal Infection | Products > Disease Areas > Alzheimer's Disease | Products > Disease Areas > Obesity | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Stem Cell/Wnt | Products > Research Areas > Neurological Disease | Products > Research Areas > Metabolic Disease | Products > Research Areas > Infection | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > VEGFR | Products > Signaling Pathways > ATM/ATR | Products > Signaling Pathways > PTEN | Products > Signaling Pathways > Akt | Products > Signaling Pathways > mTOR | Products > Signaling Pathways > HIF/HIF Prolyl-Hydroxylase | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Notch | Products > Signaling Pathways > Cholinesterase (ChE) | Products > Signaling Pathways > Amyloid-β | Products > Signaling Pathways > γ-secretase | Products > Signaling Pathways > Ferroptosis | Products > Signaling Pathways > Fungal

Product Information

• Catalog No.: HY-N11709
• CAS No.: 220114-28-3
• Molecular Formula: C59H90O27
• Molecular Weight: 1231.33
• Purity: 99.08%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Availability: In-stock

Source

Original product source