Neosartoricin (Fumicycline) (Compound 3), a prenylated anthracenone, is a microbial secondary metabolite. Neosartoricin can be isolated from Aspergillus fumigatus and Neosartorya fischeri . Neosartoricin has immunosuppressive activity, and significantly inhibits T-cell proliferative activity with an IC 50 of 3 μM. Neosartoricin may be beneficial to fungal defense, facilitating infection through suppressing the host adaptive immunity without involvement of primary virulence.
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