Cucurbitacin F is a tetracyclic protostane-type triterpenoid with low toxicity, antibacterial and anti-inflammatory activities, and is also a related compound of Cucurbitacin B ( HY-N0416 ). Cucurbitacin F widely exists in plants such as Cucurbitaceae plants , Quisqualis indica and Sorbaria sorbifolia . Cucurbitacin F acts as an actin aggregator and reduces cell viability in a dose-dependent manner. Cucurbitacin F induces apoptosis by triggering G2/M phase cell cycle arrest and activating the caspase-3 -dependent apoptosis .
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