Polycarpine hydrochloride (1a) is a broad-spectrum Mpro inhibitor ( IC 50 = 30 nM) that can be isolated from the Polycarpa aurata and also serves as an anti-coronaviral agent. Polycarpine hydrochloride possesses antiviral and antifungal activities, with IC 50 values of 30.0 nM and 0.12 μM against SARS-CoV-2 Mpro and PEDV Mpro , respectively.
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