Rhodojaponin VI

Overview

Rhodojaponin VI is an orally active diterpenoid compound found in hododendron molle G. Don ( Ericaceae ) (RM). Rhodojaponin VI binds rat N-Ethylmaleimide-sensitive fusion (NSF) with a Kd of 1.03 μM. Rhodojaponin VI blocks the MDM2-Notch1 signalling pathway by reducing MDM2 and Notch1 expression. Rhodojaponin VI indirectly reduces Cav 2.2 current intensity by inhibiting NSF -mediated Cav2.2 trafficking. Rhodojaponin VI alleviates glomerulonephritis progression and podocyte injury in passive heymann nephritis rats. Rhodojaponin VI also has antinociceptive effects. Rhodojaponin VI can be used for the researches of heymann nephritis and pain.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Renal Disease | Products > Disease Areas > Genitourinary Inflammation | Products > Disease Areas > Pain | Products > Disease Areas > Nephritis | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Neurological Disease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > MDM-2/p53 | Products > Signaling Pathways > Notch | Products > Signaling Pathways > Calcium Channel

Product Information

• Catalog No.: HY-N12768
• CAS No.: 37720-87-9
• Molecular Formula: C20H34O7
• Molecular Weight: 386.48
• Purity: 99.78%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Availability: In-stock

Source

Original product source