LY2811376

Overview

LY2811376 is the first orally available non-peptidic β-secretase ( BACE1 ) inhibitor with IC 50 of 239 nM-249 nM, that acts to decrease Aβ secretion with EC 50 of 300 nM, and demonstrates to have 10-fold selectivity towards BACE1 over BACE2 , and more than 50-fold inhibition over other aspartic proteases including cathepsin D , pepsin, or renin .

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Alzheimer's Disease | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Beta-secretase

Product Information

• Catalog No.: HY-10472
• CAS No.: 1194044-20-6
• Molecular Formula: C15H14F2N4S
• Molecular Weight: 320.36
• Purity: 99.62%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.5 mg/mL (7.80 mM); Clear solution
• Availability: In-stock

Source

Original product source