Pevonedistat hydrochloride

Overview

Pevonedistat (MLN4924) hydrochloride is a potent and selective NEDD8-activating enzyme (NAE) inhibitor, with an IC 50 of 4.7 nM. Pevonedistat hydrochloride induces the deregulation of S-phase DNA synthesis, thereby disrupting protein turnover mediated by cullin-RING ligase , leading to apoptosis of human tumor cells. Pevonedistat hydrochloride suppresses the growth of human tumour xenografts in mice.

Application

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Product Information

• Catalog No.: HY-10484
• CAS No.: 1160295-21-5
• Molecular Formula: C21H26ClN5O4S
• Molecular Weight: 479.98
• Purity: 98.58%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture)
• Solubility: ≥ 2.5 mg/mL (5.21 mM); Clear solution
• Availability: In-stock

Source

Original product source