(R)-Reticuline is a key intermediate and precursor in the biosynthetic pathway of morphinan alkaloids . (R)-Reticuline plays a central role in the metabolism of opium poppy ( Papaver somniferum ). (R)-Reticuline can either undergo O-methylation catalyzed by PSOMT1 , or be converted to (+)-Salutaridine via regioselective and stereoselective oxidative coupling under the action of salutaridine synthase ( CYP719B1 ). (R)-Reticuline serves as a direct precursor for the synthesis of important alkaloids such as morphine, codeine and thebaine.
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