(-)-Sesamin 2,2'-diol is a nitric oxide (NO) production inhibitor with an IC 50 of 310 μM for inhibiting LPS-induced NO production. (-)-Sesamin 2,2'-diol can be isolated from the aerial parts of Isodon japonicus . (-)-Sesamin 2,2'-diol abrogates NO production in LPS-stimulated macrophages without inducing cytotoxicity.
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