Tenidap

Overview

Tenidap (CP-66248) is an orally active dual inhibitor of 5-LOX and COX with anti-inflammatory and immunomodulatory properties. Tenidap downregulates the expression of IL-1 receptors in chondrocytes, reduces the release of pro-inflammatory cytokines such as IL-1 , IL-6 and TNF-α , and inhibits MMP production and cartilage degradation. Tenidap also blocks bone resorption and leukocyte adhesion to vascular endothelium, interferes with ion and pH changes associated with mouse sperm capacitation, and selectively enhances the activity of hKir2.3 channels ( EC 50 =1.3 μM). Tenidap is applicable to research related to rheumatoid arthritis.

Application

Products | Products > Disease Areas > Musculoskeletal and Skin Disease | Products > Disease Areas > Autoimmune Disease | Products > Disease Areas > Arthritis | Products > Disease Areas > Rheumatoid Arthritis | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > COX | Products > Signaling Pathways > Lipoxygenase | Products > Signaling Pathways > Potassium Channel | Products > Signaling Pathways > MMP

Product Information

• Catalog No.: HY-105028
• CAS No.: 120210-48-2
• Molecular Formula: C14H9ClN2O3S
• Molecular Weight: 320.75
• Purity: 99.93%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: 2.5 mg/mL (7.79 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source