Zoniporide mesylate (CP-597396 mesylate) is a potent and selective NHE-1 inhibitor with cardioprotective activity. Zoniporide inhibits 22 Na + uptake by human NHE-1 -expressing fibroblasts in a concentration-dependent manner ( IC 50 =14 nM). Zoniporide inhibits platelet swelling in vitro with an IC 50 of 0.059 μM. Zoniporide can be used in the study of cardiovascular disease .
Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Na+/H+ Exchanger (NHE)
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