Glycocholic acid

Overview

Glycocholic acid is a bile acid derivative. Glycocholic acid downregulates MDR1 , Bcl-2 , MRP1 , MRP2 and FXR , upregulates Bax , p53 , caspase-9 , caspase-3 , TGR5 and S1PR2 . Glycocholic acid inhibits multidrug resistance and efflux pumps, induces mitochondrial apoptosis , and enhances chemosensitivity. Glycocholic acid modulates related bile acid receptor signaling. Glycocholic acid suppresses growth and conjugation of Enterobacteriaceae and increases their antibiotic susceptibility. Glycocholic acid can be used for the research of colon adenocarcinoma and cholangiocarcinoma (CCA).

Application

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Product Information

• Catalog No.: HY-N1423
• CAS No.: 475-31-0
• Molecular Formula: C26H43NO6
• Molecular Weight: 465.62
• Purity: 99.90%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.08 mg/mL (4.47 mM); Clear solution
• Availability: In-stock

Source

Original product source