Glycocholic acid sodium

Overview

Glycocholic acid sodium is a bile acid derivative. Glycocholic acid downregulates MDR1 , Bcl-2 , MRP1 , MRP2 and FXR , upregulates Bax , p53 , caspase-9 , caspase-3 , TGR5 and S1PR2 . Glycocholic acid sodium inhibits multidrug resistance and efflux pumps, induces mitochondrial apoptosis , and enhances chemosensitivity. Glycocholic acid sodium modulates related bile acid receptor signaling. Glycocholic acid sodium suppresses growth and conjugation of Enterobacteriaceae and increases their antibiotic susceptibility. Glycocholic acid sodium can be used for the research of colon adenocarcinoma and cholangiocarcinoma (CCA).

Application

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Product Information

• Catalog No.: HY-N1423A
• CAS No.: 863-57-0
• Molecular Formula: C26H42NNaO6
• Molecular Weight: 487.60
• Purity: 97.0%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 2.5 mg/mL (5.13 mM); Clear solution
• Availability: In-stock

Source

Original product source