Madindoline A

Overview

Madindoline A is an orally active gp130 antagonist with a K D of 288 μM. Madindoline A inhibits IL-6 - and IL-11 -induced osteoclastogenesis, suppresses IL-6 -stimulated serum amyloid A protein production, inhibits bone resorption and bone loss, and also inhibits IL-6 - and IL-11 -dependent cell line growth, as well as IL-6 -dependent Stat3 tyrosine phosphorylation. Madindoline A is applicable for the research of hormone-dependent postmenopausal osteoporosis.

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Mineral Metabolism | Products > Disease Areas > Osteoporosis | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > JAK/STAT Signaling | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > Interleukin Related | Products > Signaling Pathways > STAT

Product Information

• Catalog No.: HY-N14323
• CAS No.: 184877-64-3
• Molecular Formula: C22H27NO4
• Molecular Weight: 369.45
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source