Disorazol A

Overview

Disorazol A1 is an tubulin inhibitor with antifungal activity. Disorazol A1 functions by inhibiting tubulin polymerization, interfering with microtubule formation, blocking mitosis , thus arresting the cell cycle at the G 2 /M phase and inducing apoptosis . Disorazol A1 also exhibits an inhibitory effect against L929 mouse fibroblasts with an IC 50 value of 3 pM. Disorazol A1 causes the accumulation of p53 protein in the cell nucleus. Disorazol A1 is promising for research of cancers.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Cytoskeleton | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Mitosis | Products > Signaling Pathways > Microtubule/Tubulin | Products > Signaling Pathways > Fungal

Product Information

• Catalog No.: HY-N14734
• CAS No.: 158181-47-6
• Molecular Formula: C43H54N2O10
• Molecular Weight: 758.90
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source