α-Thujaplicin, the isomer of Hinokitiol ( HY-B2230 ), is an antimicrobial agent. α-Thujaplicin can be isolated from Aomori Hiba ( Thujopsis dolabrata SIEB. et ZUCC. var. hondai MAKINO ). α-Thujaplicin shows inhibition of Carboxypeptidase A ( IC 50 : 32.4 μM). α-Thujaplicin shows rather strong antifungal activity against seven kinds of plant-pathogenic fungi, their MIC s being in the range of 12.0-50.0 μg/mL. α-Thujaplicin shows clear antibacterial activity against Legionella pneumophila SG 1 and L. pneumophila SG 3, and their MICs are in the range of 12.5-50 μg/mL. α-Thujaplicin shows antibacterial activity against Enterococcus faecalis IFO-12965 with a MIC of 1.56 μg/mL. α-Thujaplicin shows germination inhibition toward the seed of Echinochloa utilis Ohwi et Yabuno . α-thujaplicin inhibits lymphocytic leukemia, stomach cancer , Ehrlich’s ascites carcinoma.
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