Cladophorol A

Overview

Cladophorol A is a cyclic GMP-AMP synthase ( cGAS ) inhibitor. Cladophorol A binds to the conserved adenosine nucleobase binding site within the cGAS active site to inhibit its catalytic activity. Cladophorol A effectively inhibits the overactivation of the cGAS-STING pathway with an IC 50 of 370 nM. Cladophorol A inhibits asexual blood-stage Plasmodium falciparum with an EC 50 of 0.7 μg/mL. Cladophorol A can be used for the researches of inflammatory disease and malaria.

Application

Products | Products > Disease Areas > Plasmodium Infection | Products > Disease Areas > Infection | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Parasitic Infection | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Infection | Products > Signaling Pathways > Cyclic GMP-AMP Synthase | Products > Signaling Pathways > STING | Products > Signaling Pathways > Parasite

Product Information

• Catalog No.: HY-N15159
• CAS No.: 146776-30-9
• Molecular Formula: C13H8O6
• Molecular Weight: 260.20
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source