Hyrtiosal, found in the marine sponge Hyrtios erectus , is an inhibitor of the N-terminal domain (NTD) of HIV-1 integrase ( HIV-1 IN ) with an IC 50 value of 9.60-0.86 μM. Hyrtiosal binds to the Ser17, Trp19, and Lys34 sites on the NTD of HIV-1 IN, inhibiting the binding of HIV-1 viral DNA to integrase and interfering with the formation of the pre-integrated complex of HIV-1 . Hyrtiosal is promising for research of anti-HIV agents.
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