Zaluzanin C is a sesquiterpene lactone and antifungal agent. Zaluzanin C is isolated from the leaves of Vernonia arborea . Zaluzanin C inhibits mtROS-mediated NF-κB activity, as well as LPS- and TNF-α-induced mtROS production. Zaluzanin C alleviates mtROS-mediated mitochondrial dysfunction, enhances Mitophagy , and increases the mRNA levels of fatty acid oxidation genes and mitochondrial biogenesis factors. Zaluzanin C inhibits the formation of advanced glycation end products and α-glucosidase activity. Zaluzanin C improves intracellular lipid accumulation. Zaluzanin C exhibits anti-inflammatory, antioxidant, antifungal , anticancer and pro-osteogenic activities. Zaluzanin C can be used in studies related to non-alcoholic fatty liver disease and obesity.
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