Merulidial (Compound 1) is an antibiotic and cytotoxic agent with a sesquiterpene dialdehyde structure. Merulidial significantly inhibits the germination of spores and the hyphal growth of the wood-roting basidiomycete Heterobasidion annosum ( H. annosum ) and the saprophytic mould Cladosporium cucumerinum ( C.cucumerinum ). Merulidial also inhibits a variety of bacteria, algae and DNA synthesis of ECA cells. Merulidial shows a strong anticancer activity with IC 50 s of 20 and 10 μg/mL for ECA and L1210 cells, respectively .
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