VSA 1, a semisynthetic QS-21 ( HY-101092 ) analog, is a saponin adjuvant . VSA 1 potentiates antigen-specific IgG1 and IgG2a immune responses in BALB/c mice, indicating a mixed Th1/Th2 immune response. VSA 1 significantly improves vaccine efficacy after primary immunization and enhances homologous protection.
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