Thienodolin

Overview

Thienodolin (MJ 286A) is an alkaloid that has been found in S. albogriseolus . Thienodolin inhibits nitric oxide production in LPS ( HY-D1056 )-stimulated RAW 264.7 murine macrophage cells with an IC 50 value of 17.2 μM. Thienodolin suppresses iNOS , blocks the degradation of IκBα , attenuates NF-κB p65 accumulation in the nucleus, and reduces the phosphorylation level of STAT1 at Tyr701. Thienodolin can be used for the study of inflammation.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > JAK/STAT Signaling | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > STAT

Product Information

• Catalog No.: HY-N16376
• CAS No.: 149127-27-5
• Molecular Formula: C11H7ClN2OS
• Molecular Weight: 250.70
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source