7-O-Galloyl-D-sedoheptulose

Overview

7-O-Galloyl-D-sedoheptulose is an orally effective polyphenolic compound. 7-O-Galloyl-D-sedoheptulose lowers the serum levels of glucose, leptin , insulin , C-peptide, resistin, TNF-α , IL-6 , and increases the serum level of adiponectin . 7-O-Galloyl-D-sedoheptulose significantly reduces the levels of ROS and lipid peroxidation products ( TBARS ) by down-regulating the protein expression of NADPH oxidase subunit Nox-4 and p22phox. 7-O-Galloyl-D-sedoheptulose down-regulates NF-κB and related pro-inflammatory factors ( COX-2 , iNOS ), inhibits the phosphorylation of JNK and the activity of its downstream AP-1 . 7-O-Galloyl-D-sedoheptulose reduces the expression of TGF-β1 and fibronectin, indicating its potential in anti-tissue fibrosis. 7-O-Galloyl-D-sedoheptulose can be used for the study of type 2 diabetes and its hepatic and pancreatic complications.

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Glucose Metabolism | Products > Disease Areas > Type 2 Diabetes | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > TGF-beta/Smad | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > NADPH Oxidase | Products > Signaling Pathways > Reactive Oxygen Species (ROS) | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > COX | Products > Signaling Pathways > NO Synthase | Products > Signaling Pathways > JNK | Products > Signaling Pathways > AP-1 | Products > Signaling Pathways > TGF-β Receptor | Products > Signaling Pathways > TNF Receptor | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-N16527
• CAS No.: 233690-85-2
• Molecular Formula: C14H18O11
• Molecular Weight: 362.29
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source