5-Hydroxynoracronycine is a selective inhibitor targeting Leishmania , HIV-1 protease, and nitric oxide (NO) production. 5-Hydroxynoracronycine has an IC 50 of 93.1 μmol/L against HIV-1 protease and an IC 50 of 0.19 mg/mL for scavenging DPPH free radicals. 5-Hydroxynoracronycine exerts anti-leishmanial, anti-HIV, antioxidant and antibacterial activities by inhibiting pathogen proliferation, enzyme activity and inflammation-related NO excessive production. 5-Hydroxynoracronycine can be used in the research of leishmaniasis, HIV infection, and inflammation-related diseases.
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