Clausenidin

Overview

Clausenidin is a selective inhibitor targeting apoptosis -related pathways, including the mitochondrial pathway and death receptor pathway, and vascular endothelial growth factor ( VEGF ). Clausenidin induces mitochondrial membrane depolarization by activating caspase-3 , caspase-8 and caspase-9 , upregulating the pro-apoptotic protein Bax and downregulating the anti-apoptotic protein Bcl-2 . Clausenidin also inhibits VEGF expression and blocks angiogenesis, exerting anti-tumor activity. Clausenidin has inhibitory effects against Mycobacterium tuberculosis (MIC=200 μg/mL). Clausenidin can induce apoptosis in liver cancer cells, arrest the cell cycle in the G2/M phase, and inhibit tumor angiogenesis. Clausenidin can be used in the research of malignant tumors such as liver cancer .

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Liver Cancer | Products > Disease Areas > Digestive System Cancer | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Caspase | Products > Signaling Pathways > Bacterial | Products > Signaling Pathways > Bcl-2 Family | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > VEGFR

Product Information

• Catalog No.: HY-N16771
• CAS No.: 28384-44-3
• Molecular Formula: C19H20O5
• Molecular Weight: 328.36
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source